Biotechnology smart control over stem cell fate commitment at nanoscale
نویسندگان
چکیده
منابع مشابه
miRNA activity directs stem cell commitment to a particular fate.
Extra-cellular ligands and cytokines instruct stem cells to pick specific fates and to activate corresponding genetic programs into differentiation. When a stem cell responds to such an external cue, it is first specified to take a particular differentiation route and then becomes irreversibly obliged or committed, to its future fate. Only later, upon full activation of the new genetic program ...
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Embryonic stem (ES) cells are derived from the inner cell mass of the preimplantation embryo and are pluripotent, as they are able to differentiate into all cell types of the adult organism. Once established, the pluripotent ES cells can be maintained under defined culture conditions, but can also be induced rapidly to differentiate. Maintaining this balance of stability versus plasticity is a ...
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Tissue engineering requires tight control of stem cell function. Among many physical signals such as stretch and perfusion, geometrical cues have received much attention and have widely been recognized as an important factor in scaffold design. Here we review a variety of approaches that control stem cell fate at different levels of strictness, including micro-contact printing, microwells, dire...
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ژورنال
عنوان ژورنال: Science China Materials
سال: 2017
ISSN: 2095-8226,2199-4501
DOI: 10.1007/s40843-017-9180-6